We propose PRECEDE, a precedent-guided co-scientist for side-effect-aware drug redesign that revises a parent compound to mitigate a specified side effect while preserving therapeutic function. Rather than isolated molecular generation, PRECEDE frames redesign as evidence-grounded reasoning over drug--side-effect associations, biomedical knowledge graphs, and precedents of safety-driven optimization, coordinated by an LLM orchestrator with explicit policies and human-review checkpoints. We position PRECEDE as a human-supervised AI-for-science workflow in which hypotheses remain auditable, falsifiable, and bounded by prior pharmacology.
Long-tailed learning couples two sources of poor generalization: head classes dominate training exposure, while under-represented classes often converge to sharper regions of the loss landscape. Conventional re-sampling addresses the former without considering geometry, whereas e…
Despite rapid progress, most existing vision-language models (VLMs) built from 2D visual inputs often struggle when handling various 3D tasks that require fine-grained spatial understanding and reasoning. To bridge this gap, we present VLM-IE3D, a unified framework that enhances…
With the rapid adoption of long-context large language models (LLMs), the continuously growing KV cache during decoding has become the critical memory bottleneck. To tackle this challenge, we propose HiKV, a novel algorithm-hardware co-design that exploits KV cache redundancy thr…
Utility data (e.g., electricity, water, and gas consumption), collected by ubiquitous sensors and embedded devices, often contains substantial missing values due to various factors such as device failures and data transmission issues. The data missingness can severely impact util…
The increasing deployment of large language models (LLMs) has magnified the computational and memory bottlenecks of autoregressive decoding, where low compute intensity and bandwidth-bound kernels dominate inference cost. Weight pruning offers a promising remedy, but existing met…
Test-time scaling through iterative self-evolution with environment feedback, as demonstrated by AlphaEvolve, shows remarkable performance gains. We hypothesize that the success of such evolution frameworks hinges on meta-skills, such as self-reflection with environment feedback,…