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openalexZenodo (CERN European Organization for Nuclear Research)2026-07-23Cited by 0

tjogzt/paralog-sl-predictor: v1.0 — Initial release

Tao Zhu

Delta Dependency (DD) — a single-subtraction metric for prioritizing paralog-based synthetic lethality candidates from DepMap CRISPR data across 23 solid tumor types. Highlights: DD AUROC = 0.794, outperforming 8 published deep learning methods in CV3 benchmark CPTAC proteomics validation across 7 cohorts (n = 672) PRISM drug sensitivity: 553 compounds with selective activity in driver-mutant lines Therapeutic window analysis nominates ARID1A→ARID1B (TI = 4.13) Companion R package: devtools::install_github("tjogzt/paralogSL") Data: DepMap 26Q1 · CPTAC · PRISM · TCGA | License: MIT

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openalexZenodo (CERN European Organization for Nuclear Research)2026-07-26

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openalexZenodo (CERN European Organization for Nuclear Research)2026-08-14

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Also available via: European Organization for Nuclear Research

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openalexZenodo (CERN European Organization for Nuclear Research)2026-08-11

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openalexZenodo (CERN European Organization for Nuclear Research)2026-08-09

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Also available via: European Organization for Nuclear Research

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openalexZenodo (CERN European Organization for Nuclear Research)2026-08-12

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