Robust out-of-the-box performance is essential for the clinical deployment of deep learning models in medical imaging. An important but underexplored factor affecting model generalisability is intensity normalisation, particularly for magnetic resonance imaging (MRI), where image intensities vary across scanners and protocols. In this study, we systematically compared seven normalisation methods and their impact on the performance of a 3D U-Net model for meniscus segmentation from knee MRI. The methods included standard scaling approaches, histogram-based techniques, and a Gaussian Mixture Model (GMM)-based method. Models were trained on the IWOAI 2019 dataset and evaluated on both internal and external test sets (SKM-TEA) to assess generalisability. Performance was similar internally but differences were significant on external data, with Z-score, Nyúl histogram matching, and CLAHE showing greater robustness than other methods. However, these differences were small compared to the significant performance drop observed between datasets. Overall, while intensity normalisation had a measurable effect on model generalisability, its impact was limited relative to the effects of domain shift, highlighting the need for complementary strategies for robust deployment.
Accurate pixel-level classification of coronary angiograms is critical for cardiovascular disease assessment, yet the field lacks standardized evaluation protocols. In this work we demonstrate a new benchmark for the assessment of deep learning models which densely classify pixel…
Vision-language model (VLM) agents increasingly use tools to act on 3D scenes rather than only describe them. Existing 3D benchmarks score textual responses or single-object operations, leaving agent action on complete multi-object 3D scenes under evaluated. We present SceneActBe…
Dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) is essential for breast cancer management, but reliance on gadolinium-based contrast agents (GBCAs) restricts use in contraindicated populations, prolongs scan protocols, and presents environmental toxicity concerns.…
Background and Objective: Generating realistic medical images with anatomically accurate segmentation masks helps address the shortage of annotated data in medical imaging, particularly in optical coherence tomography (OCT) of mouse eyes, where manual retinal layer delineation is…
Multimodal Large Language Models (MLLMs) are emerging as core reasoning modules for embodied agents, yet it remains unclear how well general-purpose models can solve long-horizon embodied tasks from a single high-level instruction. We introduce MissionBench, a benchmark for missi…
The rapid advancement of generative models has spurred the critical need to evaluate the worst-case robustness of deepfake detectors. In this paper, we reveal a fundamental blind spot in current forensic paradigms: while existing detectors excel at capturing digital synthesis art…