Multimodal Continual Instruction Tuning (MCIT) is crucial for adapting Multimodal Large Language Models (MLLMs) to evolving a sequence of downstream tasks. Prior methods mostly utilize Mixture of Experts or expansion merge approach, primarily focusing on catastrophic forgetting, yet they still suffer from negative interference during inference, where newly learned updates overwrite useful prior knowledge and degrade overall performance. To address this, we propose SiGMA (Sign Guided Merging and Adaptation), a simple yet effective framework that mitigates negative interference with two components: sign guided adaptive tuning during training and sign guided merging at inference. Sign guided adaptive tuning reduces collisions with past knowledge and learns the current task with minimal drift, mitigating severe forgetting. Sign guided merging further improves consolidation by selectively scaling salient parameters to preserve and amplify useful task specific knowledge. Experiments on UCIT and DCL benchmarks show that SiGMA significantly reduces negative interference and outperforms state of the art MCIT methods. Our code is available at SiGMA.
The electrocardiogram (ECG) is a cornerstone of cardiac as- sessment, yet clinical deployment of deep learning models remains con- strained by limited interpretability and the hallucination risk of large language models (LLMs). Existing CNN+Grad-CAM+multimodal LLM frameworks can…
Bayesian optimization (BO) is an optimization method that sequentially proposes the next candidate explainable variables for optimizing target variables by balancing exploration and exploitation. BO is often used under a limited evaluation budget, such as hyperparameter tuning of…
The integration of large language models (LLMs) into the nuclear power industry requires outputs grounded in domain-specific knowledge. This study evaluates a 31-billion-parameter open-weight multimodal model (Gemma 4 31B-IT) on its capacity to apply nuclear knowledge by benchmar…
Accurate on-device fluid identification is essential for microfluidic applications, yet maintaining reliability under varying flow, pressure, and temperature remains a key challenge. Existing learning-based methods often treat sensor signals as domain-agnostic features, neglectin…
A rhetorical figure that Cicero and Quintilian catalogued two thousand years ago reappears, systematically, in the text of large language models: epanorthosis, the self-correction of the specimen «This is not a course. It is a journey of transformation». This essay argues that th…