Esophageal squamous cell carcinoma(ESCC) carries a poor prognosis with low survival rates, frequently due to advanced disease at diagnosis. Colonic metastasis from ESCC is exceptionally rare. This report describes the case of a 68-year-old male with locally advanced ESCC who developed metachronous colonic metastasis during follow-up after initial definitive chemoradiotherapy combined with immunotherapy. Pathological examination of a colonic biopsy confirmed metastatic squamous cell carcinoma with an immunohistochemical profile consistent with esophageal origin. The patient subsequently received systemic chemotherapy followed by combined immunotherapy, achieving a partial response on imaging evaluation. This case not only underscores the rarity of colonic metastasis in ESCC but also highlights the critical importance of maintaining vigilance for this possibility within multidisciplinary care and long-term follow-up.
Esophageal squamous cell carcinoma (ESCC) is a highly lethal malignant tumor. Immune checkpoint inhibitors (ICIs), represented by sintilimab, have become an important treatment option for advanced ESCC, but they may induce immune-related adverse events (irAEs) involving multiple…
Background Adenomatoid tumor is a rare benign neoplasm of mesothelial origin, most commonly arising in the epididymis, vas deferens, and tunica vaginalis; primary occurrence in the testis is extremely rare. Cryptorchidism is recognized as a risk factor for testicular germ cell tu…
The integration of immune checkpoint inhibitors into first-line treatment has markedly improved outcomes for extensive-stage small cell lung cancer (ES-SCLC). Adebrelimab, a PD-L1 inhibitor, demonstrated superior overall survival in the phase 3 CAPSTONE-1 trial. We present a deta…
Background Uterine adenosarcoma is a rare malignant tumor characterized by a biphasic pattern consisting of benign epithelial components and sarcomatous stroma. The subtype with sarcomatous overgrowth is more aggressive and poses significant challenges in clinical diagnosis and m…
Purpose Understanding concerns about recurrence or metastasis after nephrectomy and preferences for adjuvant therapy among patients with renal cell carcinoma (RCC) is important for facilitating shared decision-making between patients and physicians. We conducted a web-based surve…
Introduction Spinal chordomas are locally aggressive primary malignancies of bone that require en bloc surgical resection to optimize outcomes. A rare subset of spinal chordomas occur in the cervical spine, some of which involve the upper cervical spine and craniovertebral juncti…