A Novel Deep Learning Approach for Alzheimer’s Disease Detection: Attention-Driven Convolutional Neural Networks with Multi-Activation Fusion

Mohammed G. Alsubaie, Suhuai Luo, Kamran Shaukat, Weijia Zhang, Jiaming Li

Alzheimer’s disease (AD) affects over 50 million people worldwide, making early and accurate diagnosis essential for effective treatment and care planning. Diagnosing AD through neuroimaging continues to face challenges, including reliance on subjective clinical evaluations, the need for manual feature extraction, and limited generalisability across diverse populations. Recent advances in deep learning, especially convolutional neural networks (CNNs) and vision transformers, have improved diagnostic performance, but many models still depend on large labelled datasets and high computational resources. This study introduces an attention-enhanced CNN with a multi-activation fusion (MAF) module and evaluates it using the Alzheimer’s Disease Neuroimaging Initiative dataset. The channel attention mechanism helps the model focus on the most important brain regions in 3D MRI scans, while the MAF module, inspired by multi-head attention, uses parallel fully connected layers with different activation functions to capture varied and complementary feature patterns. This design improves feature representation and increases robustness across heterogeneous patient groups. The proposed model achieved 92.1% accuracy and 0.99 AUC, with precision, recall, and F1-scores of 91.3%, 89.3%, and 92%, respectively. Ten-fold cross-validation confirmed its reliability, showing consistent performance with 91.23% accuracy, 0.93 AUC, 90.29% precision, and 88.30% recall. Comparative analysis also shows that the model outperforms several state-of-the-art deep learning approaches for AD classification. Overall, these findings highlight the potential of combining attention mechanisms with multi-activation modules to improve automated AD diagnosis and enhance diagnostic reliability.