Text-to-3D systems can now synthesize a model from a single sentence, yet the result is a shape to render, not a design to edit. We present Arko-T, a 4B-parameter text-to-design model that maps natural-language intent directly into executable, parametric CAD programs. Rather than optimizing for code executability alone, Arko-T aligns every stage of the pipeline to a formal notion of design state, so that data curation, code normalization, and execution-grounded supervision all work to preserve the features, parameters, and construction logic that make a CAD artifact editable. Benchmarked against seven frontier LLMs across 12 metrics, Arko-T attains the best score on 8 and the second-best on 3 more, at roughly one-tenth the per-benchmark cost. The results suggest that targeted design-level training at moderate scale can match frontier general-purpose models on structured CAD generation.
Molecular glue degraders have emerged as a promising strategy for targeted protein degradation by inducing ternary complex formation between an E3 ubiquitin ligase and a target protein. Despite their therapeutic potential, computational design of molecular glues remains largely u…
Text-to-molecule generation is typically formulated as a one-shot sequence generation problem, where a model directly maps target descriptions to molecular representations. However, molecular descriptions often contain informative structural constraints, and violating such constr…
Autoregressive foundation models for electronic health records (EHRs) typically inherit pretraining methods from language modeling, where patient trajectories are concatenated into a single token stream and windows are sampled from that stream. In EHR data, this choice is consequ…
Autoregressive foundation models trained on tokenized electronic health records (EHRs) can support zero-shot clinical prediction, yet most operate on structured event codes alone, and do not incorporate multiple modalities in a principled way. We present a framework for condition…
Weather forecasting foundation models (FMs) are increasingly fine-tuned to predict air quality, offering fast global pollution forecasts at lower computational cost than conventional chemical transport models. These FMs are typically trained on reanalysis data and generate foreca…
Multi-branch architectures and CNN-Transformer fusion have long been regarded as effective ways to improve vehicle re-identification (Re-ID) by combining complementary representations. In this work, we revisit this assumption in the foundation-model era through a comprehensive em…