CLARK: Closed-loop Learning for Adaptive Reasoning over Knowledge Graphs

Yousef Khan, Luca Gherardini, Marco Maratea, Joel Arrais, Jose Sousa

Machine Learning models are widely used for automating classification tasks by extracting statistical patterns from data. However, their performance deteriorates if the data distribution changes, making them ill-suited to handle uncertain and evolving information. Moreover, they provide limited support for integrating prior knowledge. To address these limitations, we present CLARK (Closed-loop Learning for Adaptive Reasoning over Knowledge Graphs), a framework that integrates knowledge graphs, symbolic rule mining, and probabilistic reasoning under the Logic Programs with Markov Logic Networks (LP$^{\text{MLN}}$) formalism. Starting from CACTUS-derived KGs, CLARK translates graph structure into an LP$^{\text{MLN}}$ program and iteratively enriches it with candidate rules proposed by symbolic learners. These rules are calibrated through probabilistic weight learning, enabling reasoning under uncertainty and refinement of the underlying graph structure. We evaluate CLARK on two medical datasets, analysing both rule quality and downstream classification performance. Results demonstrate that CLARK leads to improved classification performance and more generalisable inference. Overall, CLARK provides a principled approach to constructing adaptive, interpretable, knowledge-driven models for classification.